Table 1:
Adipose cell size distribution and clinical changes at baseline and post-overfeeding
| VARIABLE | BASELINE | POST-OVERFEEDING | |
|---|---|---|---|
|
| |||
| Mean ± SD | Mean ± SD | p value (% change) | |
|
| |||
| Small Adipocytes (%) | 41 ± 21 | 56 ± 15 | 0.03 |
|
|
|||
| Peak Diameter of Large Adipocytes | 87 ± 22 | 104 ± 14 | 0.01 |
|
| |||
| Body Weight (kg) | 81.7 ± 9.8 | 88.3 ± 10.1 | <.0001 |
|
|
|||
| BMI (kg/m2) | 25.6 ± 2.3 | 27.7 ± 2.5 | <.0001 |
|
|
|||
| Body Fat (%) | 18.2 ± 4.8 | 20.9 ± 4.8 | <.0001 |
|
|
|||
| SAT (kg) | 3.8 ± 1.6 | 5.0 ± 1.8 | <.0001 |
|
|
|||
| VAT (kg) | 0.56 ± 0.54 | 0.89 ± 0.66 | <.0001 |
|
|
|||
| VAT:TAT (%) | 11.5 ± 6.2 | 14.1 ± 6.3 | 0.002 |
|
| |||
| IHL (%) | 1.7 ± 3.9 | 2.5 ± 6.2 | 0.001 |
|
|
|||
| TRIG (mg/dL) | 89.7 ± 41.9 | 94.3 ± 73.9 | 0.77 |
|
| |||
| HDL (mg/dL) | 53.1 ± 11.4 | 55.9 ± 11.5 | 0.04 |
|
|
|||
| LDL (mg/dL) | 98.8 ± 26.27 | 119.9 ± 31.6 | <.0001 |
|
| |||
| Mean BP (mm Hg) | 85.4 ± 5.5 | 86.5 ± 4.1 | 0.27 |
|
|
|||
| Glucose Infusion (mg/min·[FFM+17.7]) | |||
|
| |||
| 10 (mU/min·m2 insulin) | 2.9 ± 1.0 | 2.4 ± 0.7 | 0.005 |
|
| |||
| 50 (mU/min·m2 insulin) | 11.5 ± 2.5 | 10.7 ± 2.6 | 0.03 |
Abbreviations: Adipose Tissue, AT; Body Mass Index, BMI; Blood Pressure, BP; High-Density Lipoprotein, HDL; Intrahepatic Lipid, IHL; Low-Density Lipoprotein, LDL; Subcutaneous Abdominal Adipose Tissue, SAT; Visceral Adipose Tissue, VAT; Visceral: Total Abdominal Adipose Tissue, VAT:TAT; Triglycerides, TG