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. 2022 May 6;67(2):241–252. doi: 10.1165/rcmb.2021-0563OC

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Copyright © 2022 by the American Thoracic Society

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0. For commercial usage and reprints, please e-mail Diane Gern.

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Figure 6. — Heterogeneity of BALF monocyte-derived macrophage analyzed by scRNAseq. (A) UMAP plot depicting BALF monocyte-derived macrophage (i.e., cluster 3 of Figure 5A) from the merged biological samples. (B) UMAP plots depicting BALF monocyte-derived macrophage isolated from healthy nonsmokers (left), smokers without COPD (middle), and smokers with COPD (right). (C) Histogram showing percentage of each cluster within individual samples. (D) Heatmap depicting the 10 most upregulated genes in each cluster. (E) Dot plots showing average expression and percentage of cells expressing the indicated genes within cell clusters. (F) Histograms showing results of GO enrichment tests for the upregulated genes in clusters 3 (left) and 1 (right) as compared with the other clusters.