Figure 2.

Macromolecular properties of the purified gel-forming mucins from sputum are not significantly different between healthy and CF. SEC-MALS measurement of (A) molecular weight (Mw) and (B) radius of gyration (Rg) of mucins purified by isopycnic centrifugation from sputum (healthy, n = 10; CF stable, n = 15; and CF exacerbation, n = 24). FEV₁ percent predicted categories: 1: values ⩽36% (n = 10), 2: values >36% but ⩽65% (n = 17), and 3: values >65% (n = 10). (C) No significant differences in molecular weight and radius of gyration within the CF cohort based on FEV₁ percent predicted category.