TABLE 1.
Original and reviewed diagnosis of the study cohort
| N | Site | Specimen Type | Original diagnosis | Reviewed diagnosis | Reason for discrepancy | Fusion results |
|---|---|---|---|---|---|---|
| 1 | Major salivary | Resection | Chronic sialoadenitis | AciCC | Histology | |
| 2 | Major salivary | Resection | SDC admixed with AciCC | AciCC, high grade | Histology, IHC | |
| 3 | Major salivary | Resection | Adenocarcinoma, NOS | ACC | Histology, IHC | |
| 4 | EAC | Biopsy | Basal cell carcinoma of skin | ACC | Histology | |
| 5 | Trachea | Biopsy | PA | ACC | Histology | |
| 6 | Major salivary | Resection | EMC | ACC | Histology | |
| 7 | Oral | Resection | PAC | ACC | Histology, IHC | |
| 8 | Oral | Biopsy | PAC | ACC | Histology | |
| 9 | Oral | Biopsy | PAC | ACC favored | Histology | |
| 10 | Oral | Biopsy | Adenosquamous carcinoma | ACC | Histology, IHC, molecular | MYB fusion |
| 11 | Oral | Biopsy | PAC | ACC | Histology, IHC | |
| 12 | SNT | Resection | PD ca favor SNUC | ACC | Histology | No MYB fusion |
| 13 | SNT | Resection | ACC and adenocarcinoma NOS | ACC with high-grade transformation | Histology | |
| 14 | Parapharynx | Resection | CA ex PA | ACC with high-grade transformation | Histology, IHC | |
| 15 | Major salivary | Resection | MEC, high grade | Adenosquamous carcinoma favored | Histology | |
| 16 | Major salivary | Resection | ACC | BCA | Histology | |
| 17 | Major salivary | Resection | BCA | BCAC | Histology | |
| 18 | Major salivary | Resection | BCA | BCAC and PA | Histology, IHC | |
| 19 | Nasopharynx | Biopsy | SqCC | CCC | Histology, molecular | EWSR1 fusion |
| 20 | Oropharynx | Biopsy | SqCC | CCC | Histology, IHC, molecular | EWSR1-ATF1 |
| 21 | Oral | Biopsy | Adenocarcinoma, suggestive of SC | MEC | Histology | |
| 22 | Nasopharynx | Biopsy | Carcinoma with squamous features and focal mucin, favor adenosquamous carcinoma | MEC | Histology, molecular | MAML2 fusion |
| 23 | Major salivary | Resection | ACC | MECA | Histology | |
| 24 | Major salivary | Resection | EMC | MECA | Histology | |
| 25 | Major salivary | Resection | Oncocytic carcinoma | MECA | Histology, IHC | |
| 26 | Major salivary | Resection | PA | MECA | Histology | |
| 27 | Major salivary | Resection | PA | MECA favored | Histology | |
| 28 | Major salivary | Resection | PA | MECA favored | Histology | |
| 29 | Major salivary | Resection | PA | MECA ex PA | Histology | |
| 30 | Major salivary | Resection | PA | MECA ex PA | Histology | |
| 31 | Major salivary | Resection | PA | MECA ex PA | Histology | |
| 32 | Major salivary | Resection | Adenocarcinoma ex PA | MECA ex PA | Histology, IHC | No MAML2 fusion |
| 33 | Major salivary | Resection | MEC, high grade | NUT carcinoma | Histology, IHC, molecular | BRD4-NUTM1 |
| 34 | Major salivary | Resection | CA ex PA | PA, recurrent | Histology | |
| 35 | Major salivary | Resection | MEC | PA | Histology, molecular | No MAML2 fusion |
| 36 | Major salivary | Resection | Metastatic carcinoma | PA | Histology | |
| 37 | Major salivary | Resection | PAC | PA | Histology | |
| 38 | Oral | Resection | ACC | PAC | Histology | |
| 39 | Oral | Biopsy | Benign salivary tumor, favor monomorphic adenoma | PAC favored | Histology | |
| 40 | Oropharynx | Biopsy | MEC, high grade | PAC with high-grade transformation | Histology, IHC | |
| 41 | Major salivary | Biopsy | PA | PAC/CASG | Histology, IHC | |
| 42 | Major salivary | Resection | AciCC | SC | Histology, IHC, molecular | ETV6 fusion |
| 43 | Major salivary | Resection | AciCC | SC | Histology, IHC | No ETV6 fusion |
| 44 | Major salivary | Biopsy | MEC | SC | Histology, IHC, molecular | ETV6 fusion |
| 45 | Major salivary | Resection | MEC | SC with high-grade transformation | Histology, IHC, molecular | ETV6-NTRK3 |
| 46 | SNT | Resection | Adenocarcinoma, non-intestinal type | SC with high-grade transformation | Histology, IHC, molecular | ETV6 fusion |
| 47 | Major salivary | Resection | Adenosquamous carcinoma | SDC | Histology | |
| 48 | Major salivary | Resection | MEC, high grade | SDC | Histology | |
| 49 | Major salivary | Resection | MEC, high grade | SDC | Histology, IHC | |
| 50 | Major salivary | Resection | MEC, high grade | SDC | Histology, IHC | |
| 51 | Major salivary | Resection | MEC, high grade | SDC | Histology, IHC | |
| 52 | Major salivary | Resection | MEC, high grade | SDC | Histology, IHC | |
| 53 | Oral | Biopsy | MEC, high grade | SDC | Histology, molecular | No MAML2 fusion |
| 54 | Major salivary | Resection | MEC, low grade | SDC | Histology, IHC | |
| 55 | Major salivary | Resection | SqCC | SDC | Histology, IHC | |
| 56 | Major salivary | Biopsy | SqCC | SDC | Histology, IHC | |
| 57 | Major salivary | Biopsy | Benign | SDC (small cluster) | Histology | |
| 58 | Orbit | Resection | CA ex PA | SDC ex PA | Histology | |
| 59 | Orbit | Biopsy | SqCC | Carcinoma with basaloid features of salivary gland origin | Histology, IHC | |
| 60 | Major salivary | Resection | MEC, high grade | Carcinoma with squamous and basaloid features | Histology, molecular | No MAML2 fusion |
| 61 | Major salivary | Biopsy | MEC, high grade | Carcinoma with squamous features | Histology | |
| 62 | Oral | Biopsy | MEC | Carcinoma, differential diagnoses include SC and MEC | Histology | |
| 63 | Major salivary | Resection | MEC, high grade | Salivary carcinoma with SDC and MECA features, high grade | Histology | |
| 64 | Oral | Biopsy | Adenocarcinoma NOS | Salivary gland neoplasm with ductal and myoepithelial features. Resection diagnosis: EMC | Histology | |
| 65 | Oral | Biopsy | PAC | Salivary gland neoplasm with ductal and myoepithelial differentiation. The differential diagnosis includes ACC | Histology | |
| 66 | Major salivary | Biopsy | Mucin-producing carcinoma. Differential diagnoses include mucinous adenocarcinoma of skin adnexal origin and ACC | SMARCB1-deficient carcinoma | Histology, IHC |
Abbreviations: ACC, adenoid cystic carcinoma; AciCC, acinic cell carcinoma; BAC, basal cell adenoma; BCAC, basal cell adenocarcinoma; CA ex PA, carcinoma ex pleomorphic adenoma; CASG, cribriform adenocarcinoma of salivary gland; CCC, clear cell carcinoma; EMC, epithelial myoepithelial carcinoma; IHC, immunohistochemistry; MEC, mucoepidermoid carcinoma; NOS, not otherwise specified; PA, pleomorphic adenoma; PAC, polymorphous adenocarcinoma; SC, secretory carcinoma; SDC, salivary duct carcinoma.