Skip to main content
. 2022 Jul 29;5(12):e202201424. doi: 10.26508/lsa.202201424

Figure 1. Potential receptor binding and activation modes, domain architecture of MET agonists, and surface representation of NK1 crystal structure.

Figure 1.

(A) Possible receptor-binding modes and stoichiometries for hepatocyte growth factor/scatter factor and NK1 in the presence of heparin. (B) Schematic representation of hepatocyte growth factor/scatter factor, NK1, K1K1, K1K1 variants, K1H6, full-length c-MET, and the MET567 fragment. Individual domains (boxes) with positions of domain boundaries indicated above. CR, cysteine rich; Ig, immunoglobulin-like; SPH, serine protease homology; TK, tyrosine kinase. The transmembrane domain is indicated in red.