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. 2021 Dec 7;61(8):3317–3328. doi: 10.1093/rheumatology/keab877

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Published by Oxford University Press on behalf of the British Society for Rheumatology 2021. This work is written by a US Government employee and is in the public domain in the US.

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Fig. 4 — Expression of Type I IFN-induced genes in circulating monocytes at baseline and 5–6 years after transplant.

Expressed as fold-change in gene expression as compared with median expression of these genes in 20 healthy control donors (ND). Patients in remission after AHSCT whether drug-free (patients 1, 2 and 6) or under maintenance dose steroids (patient 5) showed a significant decline in expression of Type I IFN-induced genes; patient 7, who continued to have lupus symptoms, had elevated expression of these genes. A colour version of the figure is available at Rheumatology online. (IFI44L, blue; IFIT1, red; IFITM3, green; IRF7, purple; MX1, turquoise; PLSCR1, orange; RSAD2, gray; XAF1, brown). AHSCT: autologous haematopoietic stem cell transplantation.