Table 2. Univariate and multivariate Cox proportional hazard analysis for MCC related death, death from any cause et MCC recurrence.

Covariate	Cancer Specific survival				Overall survival				MCC Recurrence (any site)
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p	aHR (95% CI)	p	HR (95% CI)	p	aHR (95% CI)	p
Age (years)
>80.5 vs. ≤80.5	2.86 (1.08–7.54)	0.034	4.85 (1.39–16.9)	0.013	2.85 (1.37–5.95)	0.005	3.85 (1.56–9.48)	0.003	1.13 (0.50–2.56)	0.772	0.75 (0.26–2.16)	0.590
Sex
male vs. female	1.99 (0.81–4.92)	0.135	4.64 (1.31–16.41)	0.017	1.43 (0.71–2.88)	0.321	2.75 (1.10–6.84)	0.030	1.94 (0.85–4.42)	0.113	1.56 (0.57–4.28)	0.389
AJCC
3–4 vs. 1–2	1.82 (0.73–4.55)	0.196	2.16 (0.73–6.35)	0.161	0.90 (0.42–1.96)	0.800	1.65 (0.68–3.98)	0.265	1.41 (0.60–3.34)	0.431	1.64 (0.63–4.28)	0.314
Immunosuppression
present vs. absent	1.85 (0.54–6.41)	0.327	3.29 (0.79–13.71)	0.101	3.23 (1.28–8.14)	0.013	5.25 (1.82–15.2)	0.002	1.39 (0.41–4.70)	0.593	2.24 (0.60–8.34)	0.230
MCPyV status
positive vs. negative	0.26 (0.00–0.67)	0.005	0.42 (0.16–1.09)	0.076	0.29 (0.00–0.61)	0.001	0.37 (0.00–0.83)	0.017	0.23 (0.00–0.55)	0.001	0.20 (0.00–0.57)	0.002
GPC3 expression
positive vs. negative	2.24 (0.74–6.75)	0.153	4.05 (1.06–15.43)	0.040	1.58 (0.72–3.46)	0.252	2.42 (0.89–6.54)	0.082	1.45 (0.60–3.53)	0.412	1.34 (0.48–3.79)	0.576

Abbreviations: HR: Hazard Ratio; aHR: adjusted HR; CI: confidence interval; MCC: Merkel Cell Carcinoma.