Table 2. Spatial characterization of the immune response under different tumor growth conditions.

R.V. stands for recruitment volume and refers to the percentage of spatial domain occupied by voxels with cell recruitment points (where only one recruitment point is assumed per voxel); CSCs denotes cancer stem-like cells.

	Parameters			Cell spatial distributions
Panel	R	d max	R.V. (%)	Tumor	CD8+ T cells	FoxP3+ T cells
A	~ 1	Large	10	Regular shaped core, narrow region of low density at the IF. CSCs: present all over the tumor.	Uniform and high density around tumor, narrow region	Partially defined circular pattern
B	< 1	Large	10	Regular shaped core, wide region of low density at the IF. CSCs: High and low gradients, widely spread	Non-uniform and low density around tumor, wide region	No clear pattern
C	~ 1	Small	10	Non-regular core, narrow region of low density at the IF. CSCs: present all over the tumor.	Uniform and high density around tumor, narrow region	Partially defined circular pattern
D	< 1	Large	30	Regular shaped core, wide region of low density at the IF. CSCs: High and low gradients, widely spread	Non-uniform and high density around tumor, wide region	No clear pattern