Table 3. Spatial characterization of the immune response under different tumor growth conditions and immunotherapy.

R.V. stands for recruitment volume as defined in Table 2; CSCs denotes cancer stem-like cells.

	Parameters			Cell spatial distributions
Panel	R	d max	R.V. (%)	Tumor	CD8+ T cells	FoxP3+ T cells
A	~ 1	Large	10	Regular shaped core, finger structures and clusters at the IF. CSCs: present all over the tumor.	Uniform and high density around tumor, narrow region	No pattern, a few hotspots
B	< 1	Large	10	Regular shaped core, finger structures at the IF. CSCs: Low gradients, widely spread	Non-uniform density around tumor, wide region	No pattern, several hotspots
C	~ 1	Small	10	Non-regular shaped core and finger structures at the IF. CSCs: mostly present in the body of the tumor	Uniform and high density around tumor, narrow region	No pattern, a few hotspots
D	< 1	Large	30	Regular shaped core, finger structures and clusters at the IF. CSCs: Low gradients, widely spread	Non-uniform density around tumor, wide region	No pattern, several hotspots