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. 2022 Aug 3;8(31):eabo5546. doi: 10.1126/sciadv.abo5546

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Fig. 4. — (A) Overlay of PTP1B (white), TCPTP (light gray), STEP (dark gray), and HePTP (black). Residues surrounding helix α4 are shown as sticks and colored by conservation within the PTP family. Left: Front view looking down helix 4 from the active site (yellow star; catalytic Cys shown in orange sticks). Pink arrow indicates the view of the hydrophobic platform (curved magenta line) shown in (B). Right: Same overlay rotated by 180°. (B) PTP1B is shown as a surface and colored according to PTP family sequence conservation [most conserved (magenta) and least conserved (teal)]. Left: Same orientation as in (A), left. Right: Same orientation as in (A), right. Middle: View of helix α4 looking down illustrating the conserved hydrophobic platform and the increased variability at the α3-α4 junction. (C) Residues (shown as sticks) that comprise the conserved hydrophobic platform that support helix α4 are colored according to conservation and labeled (underline indicates a group 2 residue). (D) Residues (shown as sticks) illustrating the increased variability at the C-terminal portion of helix α4 adjacent to the N terminus of helix α3. Residues are colored and labeled as in (C).