Fig. 5. Enrichment analysis of PC/NC genes with genes whose expression levels correlate with the tissue-specific cancer incidence across human tissues and whose knockout causes cancer-related phenotypes in mice.

(A) Summary of the GSEA results of the top PC/NC genes from the MLTAW correlation in all species or mammals for genes whose expression levels correlate with the tissue-specific cancer incidence across human tissues (38). Dot size corresponds to gene set size. Dot color denotes negative log₁₀ adjusted P value from GSEA; gray corresponds to adjusted P ≥ 0.1. Positive normalized enrichment score (x axis) corresponds to enrichment by genes whose higher expression is associated with higher cancer incidence across human tissues and vice versa. (B) Summary of enrichment (via GSEA) for mouse genes whose knockout causes cancer-related phenotypes in the genes whose conservation scores correlate with MLCAW in all mammals or specifically rodents. “incidence.increase” denotes the mouse genes whose knockout results in an increase in observed cancer incidence obtained from the MGI database, similarly for other gene sets listed on the x axis. Dot size and color are interpreted as in (A). Positive normalized enrichment score (y axis) corresponds to enrichment by PC genes, and vice versa for NC genes.