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. 2022 Jun 27;87(14):9391–9398. doi: 10.1021/acs.joc.2c00694

Table 2. Results for the Synthesis of Pyrrolidinone-Fused Piperazine-2,6-diones 7 from Pyrrolidinones 6.

entry 6 (R1) 7 (%) dra
1 6a (H) 7a (84) b
2 6b (Ph) 7b (89) >95:5
3 6c (CH(CH3)2) 7c (82) >95:5
a

Determined by 1H NMR spectroscopy in the reaction mixture.

b

Racemic mixture.