Movie 5. Evolutionary conservation of the NUP88^NTD•NUP98^APD architecture.

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A 360° rotation of the NUP88^NTD•NUP98^APD cocrystal structure and the previously determined crystal structures of S. cerevisiae Nup82^NTD•Nup116^CTD•Nup159^TAIL (PDB ID 3PBP) (59) and C. thermophilum Nup82^NTD•Nup145N^APD•Nup159^TAIL (PDB ID 5CWW) (11), colored as in fig. S77.