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. Author manuscript; available in PMC: 2022 Aug 3.
Published in final edited form as: Science. 2022 Jun 10;376(6598):eabm9129. doi: 10.1126/science.abm9129

Fig. 8. Architecture of the human NPC cytoplasmic face.

Fig. 8.

Near-atomic composite structure of the human NPC generated by docking individual nup and nup complex crystal and cryo-EM structures into a ~12Å cryo-ET map of the intact human NPC, viewed from (A) the cytoplasmic face, and (B) the central transport channel, as a cross-section. Newly placed structures include the quantitatively docked NUP358NTD and the manually docked NUP88NTD•NUP98APD, NUP214NTD•DDX19, GLE1CTD•NUP42GBM, ELYSNTD, and a CFNC-hub model. The nuclear envelope is rendered as a grey isosurface. Nups are shown in cartoon representation and colored according to the legend.