Table 3.
Demographic characteristics and laboratory data in children with active SJIA with and without MAS according to the 2016 MAS classification criteria.
| sJIA with MAS | sJIA without MAS | P value | |
|---|---|---|---|
| Patients | 8 | 24 | |
| Age at onset (years) | 11.5 (3.1-15.3) | 10.8 (6.4-12.8) | 0.761 |
| Gender (f/m) | 5/3 | 9/15 | 0.217 |
| Ferritin (μg/L) | 3786 (2246-8577) | 695 (243-2551) | 0.006 |
| Platelets (×109/L) | 190 (137-272) | 425 (317-498) | 0.001 |
| Fibrinogen (μmol/L) | 10.3 (4.9-10.9) | 18.1 (11.4-21.5) | 0.008 |
| Triglycerides (mmol/L) | 3.0 (1.8-5.8) | 1.3 (1.1-2.1) | 0.003 |
| ALT (U/L) | 128 (20-167) | 13 (9-21) | 0.006 |
| LDH (U/L) | 697 (454-1153) | 260 (198-321) | 0.003 |
| WBC (×109/L) | 7.1 (5.5-11.4) | 16.0 (9.2-23.4) | 0.007 |
| Neutrophils (×109/L) | 4.0 (3.7-4.4) | 12.6 (6.1-20.8) | 0.002 |
| ESR (mm/hr) | 45 (34.8-81.8) | 74 (50.8-96) | 0.030 |
| CRP (mg/L) | 41.3 (10.8-78.9) | 104.6 (38.6-134.3) | 0.058 |
| Hb (mmol/L) | 7.0 (6.0-7.3) | 7.0 (5.9-7.3) | 0.794 |
| Ferritin/ESR ratio | 127.1 (47.6-269.7) | 10.5 (4.3-38.3) | <0.001 |
| MS score | -0.95 (-2.2–(+0.18)) | - 4.7 (-5.3–(-2.5)) | 0.003 |
ALT: alanine aminotransferase; LDH: lactate dehydrogenase; WBC: white blood cells; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; Hb: hemoglobin. Values are expressed as median with interquartile range in parenthesis. P values are obtained using Mann–Whitney U test for comparison.