TABLE 5.
Effect of vitamin D supplementation on physical function and inflammatory markers1
| Mean/percentage difference (95% CI) | P value | |
|---|---|---|
| Physical function (n = 155) | ||
| 6-min walking test, m | 34 (−4, 71) | 0.08 |
| Handgrip strength, kg | 1.15 (−1.20, 3.50) | 0.34 |
| Spirometry (n = 154) | ||
| FEV1, %predicted | −0.91 (−6.15, 4.34) | 0.73 |
| FVC, %predicted | −2.52 (−7.72, 2.67) | 0.34 |
| Maximal respiratory mouth pressures (n = 150) | ||
| MIP, kPa | −0.47 (−2.74, 1.79) | 0.68 |
| MEP, kPa | 0.28 (−0.71, 1.27) | 0.58 |
| Inflammatory markers (n = 152) | ||
| CRP, µg/mL | −6.7 (−30.2, 24.1) | 0.63 |
| IL-6, pg/mL | −13.3 (−30.6, 8.4) | 0.21 |
| LL-37, ng/mL | 0.2 (−12.1, 14.3) | 0.97 |
1Values are mean differences between the placebo and intervention groups, and derived from regression coefficients with 95% CIs. A positive value indicates a higher, and a negative value a lower, outcome in the vitamin D group. Coefficients of CRP, IL-6, and LL-37 were back transformed after ln transformation and expressed as percentage differences. All analyses were adjusted for stratification group and study center. CRP, C-reactive protein; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; MEP, maximal expiratory pressure; MIP, maximal inspiratory pressure.