FIGURE 4.

Forest plots for randomized controlled trials of acute acetate on postprandial blood insulin. Acute interventions with acetate had a main effect of 0.35 (95% CI, −0.07 to 0.77; P = 0.10) on the postintervention postprandial blood insulin iAUC (n = 35)_. A random-effects model was used to calculate standardized mean differences (squares), 95% CIs (horizontal lines), and summary effects (SMD; diamond). The study weight (expressed as a percentage) indicates the relative contribution of an individual study to the overall pooled effect size. Between-study heterogeneity was calculated using the I² statistic. A P value ≤ 0.05 was considered statistically significant. When interpreting SMDs (or effect sizes) values <0.40 were categorized as having a small effect size, values 0.40 to 0.70 as having a moderate effect size, and values >0.70 as having a large effect size. Abbreviations: iAUC, incremental AUC; SMD, standard mean difference.