Figure 3.

Vaccine protective efficacy against B.1.1.529 infection of Syrian hamsters. Following intranasal infection of vaccinated hamsters with 1000 tissue culture 50% infectious doses (TCID₅₀), nasal swabs were collected on days 2 and 4 for evaluation of (a) viral RNA load by reverse transcription quantitative polymerase chain reaction (RT-qPCR) or for (b) infectious virus by TCID₅₀ assay. On day 4, animals were sacrificed and lungs, trachea, as well as nasal turbinates harvested for quantification of (c) viral RNA load by RT-qPCR or (d) infectious virus by TCID₅₀ assay. Indicated statistical comparisons performed using two-way ANOVA with Dunnett's multiple comparisons test. *p<0.05. Comparisons without indicated p-values were non-significant (p>0.05). N = 6 per group.