Table 4.
Risk of outcomes by CSVD and infarction number in patients with minor ischaemic stroke or TIA at 1-year follow-up
| Outcomes | No. | Event, n (%) | Model 1 | Model 2 | ||
|---|---|---|---|---|---|---|
| Adjusted HR(95%CI) | p value | Adjusted HR(95%CI) | p value | |||
| Stroke | ||||||
| No CSVD with NAI | 58 | 1(1.7) | Ref. | Ref. | ||
| CSVD with NAI | 225 | 7(3.1) | 1.78(0.22–14.59) | 0.59 | 1.73(0.21–14.33) | 0.61 |
| No CSVD with SAI | 86 | 11(12.8) | 8.03(1.04–62.20) | 0.05 | 7.86(1.00–61.50) | 0.05 |
| CSVD with SAI | 312 | 40(12.8) | 7.88(1.08–57.55) | 0.04 | 7.27(0.98–54.09) | 0.05 |
| No CSVD with MAIs | 50 | 7(14.0) | 9.10(1.12–74.04) | 0.04 | 8.86(1.08–72.69) | 0.04 |
| CSVD with MAIs | 155 | 27(17.4) | 10.66(1.44–78.98) | 0.02 | 9.56(1.27–71.79) | 0.03 |
| Ischaemic stroke | ||||||
| No CSVD with NAI | 58 | 1(1.7) | Ref. | Ref. | ||
| CSVD with NAI | 225 | 7(3.1) | 1.78(0.22–14.59) | 0.59 | 1.73(0.21–14.33) | 0.61 |
| No CSVD with SAI | 86 | 11(12.8) | 8.03(1.04–62.20) | 0.05 | 7.86(1.00–61.50) | 0.05 |
| CSVD with SAI | 312 | 40(12.8) | 7.88(1.08–57.55) | 0.04 | 7.27(0.98–54.09) | 0.05 |
| No CSVD with MAIs | 50 | 7(14.0) | 9.10(1.12–74.04) | 0.04 | 8.86(1.08–72.69) | 0.04 |
| CSVD with MAIs | 155 | 27(17.4) | 10.66(1.44–78.98) | 0.02 | 9.56(1.27–71.79) | 0.03 |
| CVE | ||||||
| No CSVD with NAI | 58 | 1(1.7) | Ref. | Ref. | ||
| CSVD with NAI | 225 | 7(3.1) | 1.76(0.22–14.44) | 0.60 | 1.70(0.21–14.06) | 0.62 |
| No CSVD with SAI | 86 | 11(12.8) | 8.03(1.04–62.17) | 0.05 | 8.00(1.02–62.63) | 0.05 |
| CSVD with SAI | 312 | 40(12.8) | 7.82(1.07–57.15) | 0.04 | 7.32(0.99–54.42) | 0.05 |
| No CSVD with MAIs | 50 | 7(14.0) | 9.08(1.12–73.85) | 0.04 | 9.02(1.10–73.93) | 0.04 |
| CSVD with MAIs | 155 | 30(19.4) | 11.81(1.60–87.17) | 0.02 | 10.84(1.45–81.04) | 0.02 |
| TIA | ||||||
| No CSVD with NAI | 58 | 5(8.6) | Ref. | Ref. | ||
| CSVD with NAI | 225 | 7(3.1) | 0.32(0.10–1.07) | 0.06 | 0.36(0.10–1.28) | 0.11 |
| No CSVD with SAI | 86 | 1(1.2) | 0.13(0.02–1.15) | 0.07 | 0.18(0.02–1.64) | 0.18 |
| CSVD with SAI | 312 | 4(1.3) | 0.14(0.04–0.53) | 0.004 | 0.24(0.06–1.01) | 0.05 |
| No CSVD with MAIs | 50 | 1(2.0) | 0.22(0.03–1.93) | 0.17 | 0.30(0.03–2.64) | 0.28 |
| CSVD with MAIs | 155 | 6(3.9) | 0.40(0.12–1.39) | 0.15 | 0.63(0.17–2.40) | 0.50 |
CVE, composite vascular event; TIA, transient ischaemic attack; CSVD, cerebral small vessel disease; NAI, non-acute infarction; SAI, single acute infarction; MAIs, multiple acute infarctions; N.A., not available; Ref, reference.
Model 1: adjusted for age and sex.
Model 2: adjusted for age, gender, body mass index, history of ischaemic stroke, TIA, coronary artery disease, atrial fibrillation, hypertension, diabetes, hypercholesterolaemia, smoking status, time to randomization, qualifying event, NIHSS score on admission, and antiplatelet therapy.