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. 2022 Aug 3;12:13332. doi: 10.1038/s41598-022-17600-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differences in serotype proportion between the post-PCV7/pre-PCV13 era (purple) and post-PCV13 era (yellow). All PCV serotypes show a marked decrease due to PCV implementation, aside from serotype 3 which has also decreased but to a lesser extent. Notable exceptions to the increase in NVTs are 22F and 6C which have also decreased in the post-PCV13 era, although this followed earlier expansions.