Table 2.
Number and share of patients with specific ICD-10-GM diagnosis as disease during follow-up within two years
| ICD-10-GM Codes | Description | Baseline (365 days before diagnosis) | Follow-up (total) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total population | Cohort with HRT | Cohort without HRT | Total population | Cohort with HRT | Cohort without HRT | ||||||||
| N = 82,785 | N = 17,160 | N = 65,625 | N = 82,619 | N = 17,160 | N = 65,459 | ||||||||
| N | % | N | % | N | % | N | % | N | % | N | % | ||
| A The comorbidities were assigned based on categories of menopause rating scale II (MRS II): | |||||||||||||
| Physical disabilities (somatoforme-vegetative disorders) | |||||||||||||
| M54 | Back pain | 32,731 | 39.5 | 7,741 | 45.1 | 24,990 | 38.1 | 44,697 | 54.1 | 10,313 | 60.1 | 34,384 | 52.5 |
| N95111 | Conditions related to menopause and climacteric (inc. symptoms such as hot flashes, insomnia, headache, poor concentration associated with menopause) | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 18,043 | 21.8 | 5,230 | 30.5 | 12,813 | 19.6 |
| G43 | Migraine | 7,432 | 9.0 | 1,840 | 10.7 | 5,592 | 8.5 | 9,278 | 11.2 | 2,288 | 13.3 | 6,990 | 10.7 |
| M25.5 | Joint pain | 6,563 | 7.9 | 1,619 | 9.4 | 4,944 | 7.5 | 12,696 | 15.4 | 2,952 | 17.2 | 9,744 | 14.9 |
| G47 | sleep disorders | 5,022 | 6.1 | 1,295 | 7.5 | 3,727 | 5.7 | 9,515 | 11.5 | 2,497 | 14.6 | 7,018 | 10.7 |
| R51 | Headache | 4,480 | 5.4 | 1,098 | 6.4 | 3,382 | 5.2 | 7,700 | 9.3 | 1,905 | 11.1 | 5,795 | 8.9 |
| R42 | Dizziness | 4,393 | 5.3 | 1,069 | 6.2 | 3,324 | 5.1 | 8,255 | 10.0 | 1,994 | 11.6 | 6,261 | 9.6 |
| G44 | Other headache syndromes | 2,309 | 2.8 | 585 | 3.4 | 1,724 | 2.6 | 3,547 | 4.3 | 916 | 5.3 | 2,631 | 4.0 |
| F51 | Non-organic sleep disorders | 890 | 1.1 | 232 | 1.4 | 658 | 1.0 | 2,188 | 2.6 | 578 | 3.4 | 1,610 | 2.5 |
| R61 | Hyperhidrosis | 729 | 0.9 | 197 | 1.1 | 532 | 0.8 | 1,759 | 2.1 | 485 | 2.8 | 1,274 | 1.9 |
| F45.40 | Persistent somatoform pain disorder | 716 | 0.9 | 212 | 1.2 | 504 | 0.8 | 1,452 | 1.8 | 383 | 2.2 | 1,069 | 1.6 |
| H81.3 | Other peripheral dizziness | 302 | 0.4 | 75 | 0.4 | 227 | 0.3 | 488 | 0.6 | 109 | 0.6 | 379 | 0.6 |
| H82 | Vertigo Syndromes in Diseases Classified Elsewhere | 39 | 0.05 | 13 | 0.1 | 26 | 0.04 | 73 | 0.1 | 19 | 0.1 | 54 | 0.1 |
| Mental and behavioral disorders | |||||||||||||
| F43 | Reactions to severe stress and adjustment disorders | 8,025 | 9.7 | 1,862 | 10.9 | 6,163 | 9.4 | 14,422 | 17.5 | 3,409 | 19.9 | 11,013 | 16.8 |
| F48.0 | Neurasthenia | 3,885 | 4.7 | 912 | 5.3 | 2,973 | 4.5 | 6,644 | 8.0 | 1,531 | 8.9 | 5,113 | 7.8 |
| R53 | Malaise and fatigue | 3,571 | 4.3 | 796 | 4.6 | 2,775 | 4.2 | 7,249 | 8.8 | 1,674 | 9.8 | 5,575 | 8.5 |
| Z73 | Problems related to difficulty coping with life | 1,820 | 2.2 | 403 | 2.3 | 1,417 | 2.2 | 3,458 | 4.2 | 871 | 5.1 | 2,587 | 4.0 |
| R45 | Symptoms affecting mood | 1,518 | 1.8 | 369 | 2.2 | 1,149 | 1.8 | 2,976 | 3.6 | 759 | 4.4 | 2,217 | 3.4 |
| G93.3 | chronic fatigue syndrome | 240 | 0.3 | 57 | 0.3 | 183 | 0.3 | 505 | 0.6 | 115 | 0.7 | 390 | 0.6 |
| F38 | Other mood disorders | 48 | 0.1 | 13 | 0.1 | 35 | 0.1 | 109 | 0.1 | 27 | 0.2 | 82 | 0.1 |
| F06.6 | Organic, emotionally labile [asthenic] disorder | 19 | 0.02 | 6 | 0.03 | 13 | 0.02 | 31 | 0.04 | 6 | 0.03 | 25 | 0.04 |
| B. Diseases of the genitourinary system | |||||||||||||
| L85.3 | Xeros Cutis (inkl, Xerodermie—trockene Haut) | 350 | 0.4 | 84 | 0.5 | 266 | 0.4 | 848 | 1.0 | 192 | 1.1 | 656 | 1.0 |
| F52.0 | Lack or loss of sexual desire | 173 | 0.2 | 39 | 0.2 | 134 | 0.2 | 674 | 0.8 | 238 | 1.4 | 436 | 0.7 |
| F52.1 | Sexual aversion and lack of sexual satisfaction | < 5 | < 5 | < 5 | < 5 | < 5 | < 5 | 20 | 0.02 | 7 | 0.04 | 13 | 0.02 |
1N95.1 Coding was excluded in baseline