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. 2022 Aug 3;13:4517. doi: 10.1038/s41467-022-32145-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — MRI images for patient #23 at baseline and at two follow-up time points, as well as the corresponding mock phylogenetic tree. In this patient, unique subclones were seen at distinct locations after relapse. The boxes show the proportion of detected subclones, with each subclone having a distinct color. Dashed lines illustrate the origin/relationship of subclones/branches. For instance, the subclones belonging to the “pink” and “green” branch are interconnected by a pink and green dashed line, respectively. Known myeloma drivers are marked in bold. The tree is aligned with the functional imaging plots and as such, the length of branches does not indicate the extent of subclonal differences. A timeline of treatment and sampling alongside a detailed mock oncogenetic tree is shown in Suppl. Fig. 25. VGPR very good partial remission, CR complete remission. Source data are provided as a Source Data file.