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. 2022 Aug 3;13:4517. doi: 10.1038/s41467-022-32145-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — In a the three evolutionary patterns, which we observed in this study, are illustrated. These include (1) expansion and sweep driven by single tumor cells, (2) coexisting expanding subclones, and (3) site-unique expansions of distinct subclones, with the main difference between the second and the third pattern being the anatomical location of subclones. In b, boxplots are shown for the association between these patterns and (1) the number of PET-positive focal lesions at baseline (upper panel) and (2) the response to first-line therapy (lower panel), respectively. The boxplots show the median and the interquartile range, while the upper and lower whiskers show the highest and lowest values (excluding outliers), respectively. CR complete remission. Source data are provided as a Source Data file.