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The process of surfactant secretion and the potential pathological mechanism of MUC5B mutation. (A) The surfactant precursors are synthesized on the endoplasmic reticulum, followed by Golgi modifications, and finally secreted into the periphery by cytosolic exocytosis of the lamellar body. (B) MUC5B mutation may promote the retention of harmful substances in the lung and interfere with the normal repair of AEC.
