TABLE 4.
Multivariate Cox proportional hazard model evaluating risk factors for patient survival
| Multivariate Cox proportional hazard model | n = 43 108; LRT = 608.9; p = <.0001 | |
|---|---|---|
| Variable (reference) | HR (95% CI) | p‐value |
| Organ | ||
| Heart (Reference) | xxx | xxx |
| Heart‐lung | 2.63 (1.35–5.11) | .004*** |
| Intestine | 3.19 (1.93–5.27) | <.001*** |
| Kidney | 0.43 (0.37–0.50) | <.001*** |
| Kidney‐pancreas | 0.46 (0.31–0.66) | <.001*** |
| Liver | 0.63 (0.55–0.73) | <.001*** |
| Lung | 1.03 (0.87–1.21) | .757 |
| COVID‐19 NAT result (Donor)‐ Positive | 0.78 (0.32–1.87) | .575 |
| DCD | ||
| Yes | 1.07 (0.94–1.22) | .314 |
| Race (Recipient) | ||
| White (Reference) | xxx | xxx |
| Black | 1.02 (0.90–1.15) | .781 |
| Hispanic | 1.13 (0.99–1.30) | .071 |
| Asian | 1.29 (1.06–1.57) | .011*** |
| American Indian/Alaskan | 1.78 (1.16–2.72) | .008*** |
| Hawaiian/Pacific Islander | 1.24 (0.59–2.63) | .568 |
| Multiracial | 1.16 (0.72–1.84) | .546 |
| Cause of death (Donor) | ||
| Anoxia (Reference) | xxx | xxx |
| Cerebrovascular/Stroke | 1.21 (0.81–1.81) | .343 |
| Head trauma | 0.89 (0.62–1.28) | .539 |
| CNS tumor | 1.43 (0.74–2.75) | .290 |
| Other | 0.70 (0.49–1.00) | .050 |
| COVID‐19 infection | 0.00 (0.00‐Inf) | .988 |
| Death circumstances (Donor) | ||
| Motor vehicle accident (Reference) | xxx | xxx |
| Suicide | 0.84 (0.62–1.13) | .244 |
| Homicide | 0.87 (0.62–1.22) | .415 |
| Child abuse | 1.52 (0.73–3.14) | .264 |
| Accident (Non‐MVA) | 0.92 (0.74–1.14) | .430 |
| Natural causes | 1.01 (0.76–1.33) | .968 |
| None of above | 0.92 (0.71–1.20) | .537 |
| Death mechanism (Donor) | ||
| Intracranial hemorrhage/Stroke (Reference) | xxx | xxx |
| Drowning | 2.00 (1.16–3.44) | .012*** |
| Seizure | 1.03 (0.57–1.84) | .934 |
| Drug intoxication | 1.18 (0.78–1.79) | .444 |
| Asphyxiation | 1.14 (0.71–1.83) | .587 |
| Cardiovascular | 1.10 (0.73–1.66) | .650 |
| Electrical | 1.73 (0.41–7.35) | .458 |
| Gunshot | 1.23 (0.76–1.97) | .405 |
| Stabbing | 0.99 (0.34–2.84) | .979 |
| Blunt Injury | 1.19 (0.78–1.82) | .422 |
| SIDS | 0.00 (0.00‐Inf) | .980 |
| Natural causes | 1.27 (0.84–1.91) | .251 |
| None of above | 1.45 (0.91–2.32) | .119 |
| Inotropes (Donor) | ||
| Yes | 1.05 (0.96–1.16) | .287 |
| Race (Donor) | ||
| White (Reference) | xxx | xxx |
| Black | 1.11 (0.98–1.25) | .090 |
| Hispanic | 1.05 (0.92–1.20) | .479 |
| Asian | 1.34 (1.04–1.74) | .023*** |
| American Indian/Alaskan | 0.82 (0.44–1.54) | .541 |
| Hawaiian/Pacific Islander | 1.74 (0.77–3.90) | .182 |
| Multiracial | 0.84 (0.40–1.78) | .653 |
| Distance to donor (miles) | 1.00 (1.00–1.00) | .022*** |
| Age (years) (Recipient) | 1.02 (1.02–1.03) | <.001*** |
| BMI (kg/m2) (Recipient) | 1.01 (1.01–1.02) | .001*** |
| Time on waitlist (days) | 1.00 (1.00–1.00) | .610 |
| Age (years) (Donor) | 1.00 (0.99–1.00) | .382 |
Note: The primary study outcome variable (COVID‐19 NAT Result (Donor) ‐ Positive) is bolded.
Abbreviations: BMI, body mass index; CI, confidence interval; CNS, central nervous system; DCD, donation after cardiac death; HR, hazard ratio; LRT, likelihood ratio test; MVA, motor vehicle accident; NAT, nucleic acid test; SIDS, sudden infant death syndrome.
***
Statistically significant results (p < .05).