Table 2.

Incidence Rates of Liver Cirrhosis or Hepatocellular Carcinoma

		Cirrhosis			Hepatocellular carcinoma
NAFLD status	No.	Events	Person-years	Incidence rate†	Events	Person-years	Incidence rate†
Total population
Non-NAFLD	66 801	46	390 900	11.8	28	390 947	7.2
NAFLD/normal liver enzymes‡	41 461	31	241 741	12.8	18	241 766	7.5
NAFLD/elevated liver enzymes	21 112	63	120 940	52.1	25	121 040	20.7
Overall	129 374	140	753 581	18.6	71	753 753	9.4
Nonobese (BMI <25 kg/m 2 )
Non-NAFLD	61 053	35	357 147	9.8	22	357 194	6.2
NAFLD/normal liver enzymes‡	21 684	16	127 419	12.6	9	127 429	7.1
NAFLD/elevated liver enzymes	6686	27	39 070	69.1	8	39 118	20.5
Overall	89 423	78	523 636	14.9	39	523 741	7.5
Nonobese and without diabetes
Non-NAFLD	60 133	30	351 684	8.5	21	409 526	5.1
NAFLD/normal liver enzymes‡	20 048	11	117 755	9.3	5	117 761	4.3
NAFLD/elevated liver enzymes	6079	20	35 538	56.3	5	35 572	14.1
Overall	86 260	61	504 977	12.1	31	562 859	5.5

Abbreviation: NAFLD: nonalcoholic fatty liver disease.

^†per 100,000 person-years

^‡Normal liver enzyme levels defined by ALT < 40 and AST < 37 IU/L for male and ALT < 31 and AST < 31 IU/L for female participants.