Table 3.

Risk for Liver Cirrhosis and Hepatocellular Carcinoma According to NAFLD Status

	Crude		Adjusted
Outcome	HR (95% CI)	P value	HR (95% CI)	P value
Cirrhosis
Total population
Non-NAFLD	1.00 (reference)		1.00 (reference)
NAFLD/normal liver enzymes†	1.09 (0.69–1.72)	.7064	0.73 (0.46–1.16)	.1832
NAFLD/elevated liver enzymes	4.47 (3.05–6.53)	<.0001	3.51 (2.36–5.22)	<.0001
	P for trend	<.0001	P for trend	<.0001
Nonobese (BMI <25 kg/m2)
Non-NAFLD	1.00 (reference)		1.00 (reference)
NAFLD/normal liver enzymes†	1.28 (0.71–2.31)	.4176	0.77 (0.42–1.41)	.3980
NAFLD/elevated liver enzymes	7.05 (4.27–11.64)	<.0001	4.48 (2.66–7.55)	<.0001
	P for trend	<.0001	P for trend	<.0001
Nonobese and without diabetes
Non-NAFLD	1.00 (reference)		1.00 (reference)
NAFLD/normal liver enzymes†	1.09 (0.55–2.18)	.8028	0.79 (0.39–1.60)	.5158
NAFLD/elevated liver enzymes	6.60 (3.75–11.62)	<.0001	5.22 (2.94–9.27)	<.0001
	P for trend	<.0001	P for trend	<.0001
Hepatocellular carcinoma
Total population
Non-NAFLD	1.00 (reference)		1.00 (reference)
NAFLD/normal liver enzymes†	1.04 (0.58–1.88)	.8970	0.57 (0.31–1.04)	.0646
NAFLD/elevated liver enzymes	2.90 (1.69–4.98)	.0001	1.91 (1.08–3.38)	.0256
	P for trend	.0004	P for trend	.0005
Nonobese (BMI <25 kg/m2)
Non-NAFLD	1.00 (reference)		1.00 (reference)
NAFLD/normal liver enzymes†	1.14 (0.53–2.48)	.7345	0.67 (0.31–1.49)	.3292
NAFLD/elevated liver enzymes	3.32 (1.48–7.46)	.0036	2.27 (0.99–5.23)	.0542
	P for trend	.0147	P for trend	.0405
Nonobese and without diabetes
Non-NAFLD	1.00 (reference)		1.00 (reference)
NAFLD/normal liver enzymes†	0.71 (0.27–1.88)	.4896	0.49 (0.18–1.31)	.1561
NAFLD/elevated liver enzymes	2.36 (0.89–6.26)	.0845	1.99 (0.74–5.30)	.1707
	P for trend	.3201	P for trend	.0888

Abbreviation: NAFLD: nonalcoholic fatty liver disease; CI: confidence interval; HR: hazard ratio.

Adjusted for age, sex, platelet count, alpha-fetoprotein, and diabetes.

^†Normal liver enzymes defined by ALT < 40 and AST < 37 IU/L for male and ALT < 31 and AST < 31 IU/L for female participants.