Table 6.
The effects of coffee intake on liver enzymes and histology in patients with chronic alcohol consumption
| Non-coffee drinker (n=5) | Occasional drinker (n=21) | Regular drinker (<5 yr) (n=14) | Regular drinker (>5 yr) (n=15) | Total (n=55) | p | |
|---|---|---|---|---|---|---|
| Age (Y) | 42.3±9.1 | 46.4±10.2 | 44.0±8.3 | 45.1±9.8 | 45.2±10.3 | 0.466 |
| Sex [M (%)] | 2 (40.0) | 11 (52.3) | 9 (64.2) | 9 (60.0) | 31 (56.3) | 0.640 |
| BMI (kg/m2) | 27.9±5.6 | 28.0±5.8 | 26.3±5.3 | 25.4±6.6 | 27.3± 5.3 | 0.180 |
| Liver enzymes | ||||||
| ALT (U/L) | 70.1±24.2 | 75.2±18.4 | 35.8±11.7 | 26.3±10.2 | 56.1±15.1 | 0.038 |
| AST (U/L) | 60.7±14.6 | 47.5±11.6 | 41.0±11.1 | 19.1 ±14.7 | 45.8±11.6 | 0.046 |
| GGT (U/L) | 108.6±10.3 | 112±16.9 | 95.2±15.1 | 89.0±10.1 | 106.6±16.4 | 0.035 |
| Steatosis on USG | 4 (80.0) | 9 (42.8) | 5 (35.7) | 3 (20.0) | 21 (38.1) | 0.020 |
| TE Findings TE LSM (kPa) |
6.98±3.90 | 6.92±3.93 | 6.08±3.31 | 4.02± 2.19 | 6.49±3.86 | 0.012 |
| TE CAP (dB/m) | 283.504±71.6 | 296.93±89.22 | 232.05±58.03 | 208.73±62.1 | 240.47±85.1 | 0.021 |
Y: Year; M: Male; BMI: Body mass index; USG: Ultrasonography; TE: Transient elastography; LSM: Liver stiffness measure; CAP: Controlled attenuation parameter; NAS: NAFLD activity score. Results expressed as number (%) or median (range) unless specified otherwise. P-value for comparison of all groups.