Table 4.
Changes in COVID‐19 symptoms. Questionnaire on Day 7, by dose group and overall.
| Day 7 – Follow‐up | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 × 108 (N = 5) | 5 × 108 (N = 5) | 1 × 109 (N = 20) | 1 × 1010 (N = 5) | Total (N = 35) | ||||||
| N | % | N | % | N | % | N | % | N | % | |
| A | ||||||||||
| Stuffy or runny nose | ||||||||||
| Worsened | – | – | 1 | 25.00 | 1 | 5.56 | – | – | 2 | 6.45 |
| No change | 5 | 100.00 | 3 | 75.00 | 12 | 66.67 | 2 | 50.00 | 22 | 70.97 |
| Improved | – | – | – | – | 5 | 27.78 | 2 | 50.00 | 7 | 22.58 |
| Sore throat | ||||||||||
| Worsened | – | – | – | – | 2 | 11.11 | – | – | 2 | 6.45 |
| No change | 5 | 100.00 | 4 | 100.00 | 14 | 77.78 | 3 | 75.00 | 26 | 83.87 |
| Improved | – | – | – | – | 2 | 11.11 | 1 | 25.00 | 3 | 9.68 |
| Shortness of breath (difficulty breathing) | ||||||||||
| Worsened | – | – | – | – | – | – | – | – | – | – |
| No change | 1 | 20.00 | 1 | 25.00 | 5 | 27.78 | 1 | 25.00 | 8 | 25.81 |
| Improved | 4 | 80.00 | 3 | 75.00 | 13 | 72.22 | 3 | 75.00 | 23 | 74.19 |
| Cough | ||||||||||
| Worsened | – | – | – | – | – | – | – | – | – | – |
| No change | 2 | 40.00 | 2 | 50.00 | 4 | 22.22 | 2 | 50.00 | 10 | 32.26 |
| Improved | 3 | 60.00 | 2 | 50.00 | 14 | 77.78 | 2 | 50.00 | 21 | 67.74 |
| Low energy or tiredness | ||||||||||
| Worsened | – | – | – | – | – | – | – | – | – | – |
| No change | 3 | 60.00 | 2 | 50.00 | 5 | 27.78 | 3 | 75.00 | 13 | 41.94 |
| Improved | 2 | 40.00 | 2 | 50.00 | 13 | 72.22 | 1 | 25.00 | 18 | 58.06 |
| Muscle or body aches | ||||||||||
| Worsened | – | – | – | – | 1 | 5.56 | – | – | 1 | 3.23 |
| No change | 2 | 40.00 | 2 | 50.00 | 6 | 33.33 | 3 | 75.00 | 13 | 41.94 |
| Improved | 3 | 60.00 | 2 | 50.00 | 11 | 61.11 | 1 | 25.00 | 17 | 54.84 |
| Headache | ||||||||||
| Worsened | – | – | – | – | – | – | – | – | – | – |
| No change | 2 | 40.00 | 2 | 50.00 | 12 | 66.67 | 3 | 75.00 | 19 | 61.29 |
| Improved | 3 | 60.00 | 2 | 50.00 | 6 | 33.33 | 1 | 25.00 | 12 | 38.71 |
| Chills or shivering | ||||||||||
| Worsened | – | – | – | – | 1 | 5.56 | – | – | 1 | 3.23 |
| No change | 3 | 60.00 | 3 | 75.00 | 7 | 38.89 | 1 | 25.00 | 14 | 45.16 |
| Improved | 2 | 40.00 | 1 | 25.00 | 10 | 55.56 | 3 | 75.00 | 16 | 51.61 |
| Feeling hot or feverish | ||||||||||
| Worsened | – | – | – | – | – | – | – | – | – | – |
| No change | 2 | 40.00 | 1 | 25.00 | 6 | 33.33 | 1 | 25.00 | 10 | 32.26 |
| Improved | 3 | 60.00 | 3 | 75.00 | 12 | 66.67 | 3 | 75.00 | 21 | 67.74 |
| Nausea (feeling like you wanted to throw up) | ||||||||||
| Worsened | – | – | – | – | – | – | – | – | – | – |
| No change | 5 | 100.00 | 4 | 100.00 | 13 | 72.22 | 4 | 100.00 | 26 | 83.87 |
| Improved | – | – | – | – | 5 | 27.78 | – | – | 5 | 16.13 |
| How many times did you vomit (throw up) in the last 24 h? | ||||||||||
| Worsened | – | – | – | – | 1 | 5.56 | – | – | 1 | 3.23 |
| No change | 5 | 100.00 | 4 | 100.00 | 17 | 94.44 | 4 | 100.00 | 30 | 96.77 |
| Improved | – | – | – | – | 1 | 5.56 | – | – | 1 | 3.23 |
| B | ||||||||||
| How many times did you have diarrhea (loose or watery stools) in the last 24 h? | ||||||||||
| Worsened | – | – | – | – | – | – | – | – | – | – |
| No change | 5 | 100.00 | 3 | 75.00 | 10 | 55.56 | 3 | 75.00 | 21 | 67.74 |
| Improved | – | – | 1 | 25.00 | 7 | 38.89 | 1 | 25.00 | 9 | 29.03 |
| Rate your sense of smell in the last 24 h | ||||||||||
| Worsened | – | – | – | – | 1 | 5.56 | – | – | 1 | 3.23 |
| No change | 4 | 80.00 | 2 | 50.00 | 12 | 66.67 | 4 | 100.00 | 22 | 70.97 |
| Improved | 1 | 20.00 | 2 | 50.00 | 5 | 27.78 | – | – | 8 | 25.81 |
| Rate your sense of taste in the last 24 h | ||||||||||
| Worsened | – | – | – | – | 1 | 5.56 | 1 | 25.00 | 2 | 6.45 |
| No change | 4 | 80.00 | 2 | 50.00 | 10 | 55.56 | 3 | 75.00 | 19 | 61.29 |
| Improved | 1 | 20.00 | 2 | 50.00 | 7 | 38.89 | – | – | 10 | 32.26 |
| In the past 24 h, have you returned to your usual health (before your COVID‐19 illness)? | ||||||||||
| Worsened | – | – | – | – | – | – | – | – | – | – |
| No change | 4 | 80.00 | 2 | 50.00 | 17 | 100.00 | 4 | 100.00 | 27 | 90.00 |
| Improved | 1 | 20.00 | 2 | 50.00 | – | – | – | – | 3 | 10.00 |
| In the past 24 h, have you returned to your usual activities (before your COVID‐19 illness)? | ||||||||||
| Worsened | – | – | – | – | – | – | – | – | – | – |
| No change | 2 | 40.00 | 2 | 50.00 | 17 | 94.44 | 4 | 100.00 | 25 | 80.65 |
| Improved | 3 | 60.00 | 2 | 50.00 | 1 | 5.56 | – | – | 6 | 19.35 |
| In the past 24 h, what was the severity of your overall COVID‐19‐related symptoms at their worst? | ||||||||||
| Worsened | – | – | – | – | – | – | – | – | – | – |
| No change | 2 | 40.00 | – | – | 3 | 16.67 | 1 | 25.00 | 6 | 19.35 |
| Improved | 3 | 60.00 | 4 | 100.00 | 15 | 83.33 | 3 | 75.00 | 25 | 80.65 |