FIGURE 1.
Effect of spike protein on PAF‐induced hPRP aggregation from vaccinated and non‐vaccinated individuals. Platelet aggregation induced by PAF was defined as the difference between the 0% (PRP) baseline and the 100% (PPP) baseline: (A) hPRP from vaccinated individuals. (1A): PAF‐ induced biphasic aggregation, 6 × 10−9 M. (1B) 1 min pre‐incubation with 2 μg/ml spike protein and addition of PAF 6 × 10−9 M. (2A) PAF‐induced biphasic aggregation, 20 × 10−9 M. (2B) 1 min pre‐incubation with 2 μg/ml spike protein and addition of PAF 20 × 10−9 M. (3A) PAF‐induced biphasic aggregation, 10 × 10−9 M. (3B) PAF 10 × 10−9 M, 2 μg/ml spike protein was added just before the second wave (see arrow). (B). hPRP from non‐vaccinated individuals. (4A) PAF‐induced biphasic aggregation, 80 × 10−9 M. (4B) PAF 80 × 10−9 M, 2 μg/ml spike protein added 10 s after PAF (see arrow). (4C) PAF 80 × 10−9 M, 2 μg/ml spike protein added just before the second wave (see arrow)