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. 2022 Jun 11:10.1111/imr.13088. Online ahead of print. doi: 10.1111/imr.13088

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© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Neutralization of Alpha, Beta, and Delta variants in serum samples from individuals immunized with a single dose of Ad26.COV2.S. After vaccination with a single dose of Ad26.COV2.S, N = 6 samples at Day 29 and N = 14 samples at Day 71 were analyzed in wtVNA against the SARS‐CoV‐2 Victoria strain (D614, black dots), the B.1.1.7 (Alpha, green dots), the B.1.351 (Beta, blue dots), or the B.1.617.2 (Delta, purple dots) lineages. Dots represent IC₅₀ titers per participant. GMTs are depicted below each figure, and the fold decrease in neutralizing activity between the Victoria strain and each lineage is shown below each arrow. GMT, geometric mean titer; IC₅₀, half‐maximal inhibitory concentration; SARS‐CoV‐2, severe acute respiratory coronavirus 2; wtVNA, wild‐type virus neutralization assay