Table 3.
Correlation of quantitative T‐cell responses (overall and by subtype) after stimulation with SARS‐CoV‐2 peptides, with IgG Spike antibody fold change, and ZCS app symptom score
| Correlation with Ab response | Correlation to symptoms | |||
|---|---|---|---|---|
| Spearman's ρ | p value | Spearman's ρ | p value | |
| T Helper response | ||||
| All SARS‐CoV‐2 peptides | 0.83 | <0.0001 | 0.16 | 0.39 |
| S1 subunit | 0.74 | <0.0001 | −0.04 | 0.83 |
| S2 subunit | 0.71 | <0.0001 | 0.27 | 0.14 |
| M + N subunits | 0.83 | <0.0001 | 0.10 | 0.6023 |
| HA + INF | 0.02 | 0.91 | 0.55 | 0.0018 |
| SEB | 0.17 | 0.37 | 0.39 | 0.0315 |
| T Regulatory response | ||||
| All SARS‐CoV‐2 peptides | 0.63 | 0.0001 | 0.22 | 0.23 |
| S1 subunit | 0.48 | 0.006 | 0.02 | 0.92 |
| S2 subunit | 0.49 | 0.005 | 0.31 | 0.95 |
| M + N subunits | 0.68 | <0.0001 | −0.06 | 0.76 |
| HA + INF | −0.11 | 0.54 | 0.46 | 0.0096 |
| SEB | 0.05 | 0.79 | 0.26 | 0.16 |
| Combined T‐cell response | ||||
| All SARS‐CoV‐2 peptides | 0.79 | <0.0001 | 0.17 | 0.35 |
Abbreviations: HA + INF, Infrarix Hexa‐vaccine and Influvac antigens; M + N subunits, matrix and neucleocapsid protein complex; S1, Spike Protein subunit 1; S2, Spike Protein subunit 2; SEB, superantigen enterotoxin B.