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. 2022 Jul 19;32(39):2204692. doi: 10.1002/adfm.202204692

Figure 4.

Figure 4

Mouse immunization schedule and humoral immune response evoked by 4N4T‐DS mRNA vaccines. A) Timeline of immunization and sample collection. BALB/c mice were intramuscularly injected twice with 10 or 30 µg of 4N4T‐DS mRNA at week 0 and week 3. Mice in the control group were injected with normal saline. Serum was collected every two weeks and Spike RBD‐specific IgG titers were detected by ELISA. B) Anti‐Delta RBD IgG titer of the low‐dose group. C) Anti‐WT RBD IgG titer of the low‐dose group. D) Anti‐Delta RBD IgG titer of high‐dose group. E) Anti‐WT RBD IgG titer of the high‐dose group. Low‐dose (L) = two doses of 10 µg DS mRNA, high‐dose (H) = two doses of 30 µg DS mRNA.