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. 2022 Jul 20:10.1111/ene.15492. Online ahead of print. doi: 10.1111/ene.15492

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© 2022 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Dose‐dependent influence of rituximab (RTX) and B‐cell levels on seroconversion after SARS‐CoV‐2 mRNA vaccination. (a, b) Percentage of positive antibody responses in persons with multiple sclerosis (pwMS) on RTX in relation to (a) RTX concentration in plasma (n = 60) and (b) percentage of B cells (of live lymphocytes) in peripheral blood (n = 65). (c) Correlation between RTX concentration and percentage of B cells (of live lymphocytes) among pwMS on RTX (n = 55). (d) Correlation between RTX concentration and days since last RTX infusion (n = 60). (e) Levels of RTX concentration in plasma per serostatus and percentage of B cells. Dots represent individual data points. Kruskal–Wallis test with Dunn post hoc multiple comparison test was used for statistical analysis, and p‐values < 0.05 were considered significant. Spearman r and p‐values are shown. Ab, antibody; ns, not significant