TABLE 3.

Median differences between T1, T2 and T3 versus T0 ¹ —first sample per donor in each time frame ²

		Median	25 quadrantile	75th percentile	p‐Value
Semen volume (ml)	T0‐T1	0	−0.94	−0.45	0.29
	T0‐T2	0.2	−0.4	−0.8	0.16
	T0‐T3	−0.05	−0.5	−0.52	0.63
Sperm concentration (X 106/ml)	T0‐T1	12.5	−10	27.25	0.09
	T0‐T2	12	−8	31	0.02
	T0‐T3	3.5	−15.5	27.5	0.4
Sperm motility (%) 3 , 4	T0‐T1	−5	−9.25	5	0.62
	T0‐T2	5	−6	10	0.59
	T0‐T3	0	−5	11	0.44
Total motile count (X 106)	T0‐T1	9.8	−23.2	−24.1	0.36
	T0‐T2	31.2	2.5	57.8	0.002
	T0‐T3	4.48	−18.3	48.6	0.39

¹ T0 – pre‐vaccination baseline control; T1, T2 and T3 – short, intermediate and long‐term evaluations after 15–45, 75–125 and over 145 days after the vaccination date, respectively.

² Samples sizes: 28, 29 and 22 SD for T1, T2 and T3 comparisons, respectively.

³ Progressive and non‐progressive.

⁴ Wilcoxon for all variables except motility, which was compared by t‐test.