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. 2022 Jul 20;16:937906. doi: 10.3389/fnins.2022.937906

Figure 2.

Figure 2

Correlations between baseline BAs and depression and anxiety scores, and differences in baseline BA profiles between several participant groups. On the left: Heat map of partial Spearman rank correlations between baseline BAs and scores on the HRSD17 and Hamilton Anxiety Rating Scale and subscales, after accounting for age, sex, and body mass index. On the right: Heat map of differences in baseline BA profiles in severe vs. non-severe depressed, high vs. low anxiety and treatment-failure vs. remitter groups. T-values were used for visualization purposes and the Wilcoxon Ranked Sum Test were used to test the significance of differences. BA, Bile Acid; CA, Cholic Acid; CDCA, Chenodeoxycholic Acid; DCA, Deoxycholic Acid; GCA, Glycocholic Acid; GCDCA, Glycochenodeoxycholic Acid; GDCA, Glycodeoxycholic Acid; GHCA, Glycohyocholic Acid; GHDCA, Glycohyodeoxycholic Acid; GLCA, Glycolithocholic Acid; GUDCA, Glycoursodeoxycholic Acid; HCA, Hydroxycitric Acid; HDCA, Hyodeoxycholic Acid; HRSA-PSY, Psychic anxiety subscore of the Hamilton Anxiety Rating Scale; HRSA-SOM, Somatic anxiety subscore of the Hamilton Anxiety Rating Scale; HRSA-Total, 14-item Hamilton Anxiety Rating Scale; HRSD17, 17-item Hamilton Depression Rating Scale; LCA, Lithocholic Acid; MCA, Monocarboxylic Acid; TCA, Taurocholic Acid; TCDCA, Taurochenodeoxycholic Acid; TDCA, Taurodeoxycholic Acid; THCA, Tetrahydrocannabinolic Acid; THDCA, Taurohyodeoxycholic Acid; TUDCA, Tauroursodeoxycholic Acid; UCA, Ursocholic Acid; UDCA, Ursodeoxycholic Acid; _3S, 3 Sulfate. *uncorrected p-value < 0.05. **uncorrected p-value < 0.01. ***uncorrected p-value < 0.001.