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Therapeutic targeting of super-enhancers in cancers
The discovery of JQ1 and other bromodomain inhibitors, as well as the preferential targeting of super-enhancers, has led to the development of several first- and second-generation bromodomain inhibitors. CDK7 (CDK12/CDK13) is also attracting attention as a target for cancer therapy; CDK7 inhibitors have been reported to be effective against various types of cancer.
BETi: bromodomain and extraterminal domain inhibitor
