Table 2.
Key HSV-1-Negative and -Positive Results
| BioFire HSV− (n = 524) | PCR HSV− (n = 287) | P | BioFire HSV+ (n = 13) | PCR HSV+ (n = 2) | ||||
|---|---|---|---|---|---|---|---|---|
| ≤18 y (n = 125) | >18 y (n = 399) | ≤18 y (n = 115) | >18 y (n = 172) | ≤18 y | >18 y | All Ages | All Ages | |
| Duration of hospitalization | 16.11 (37.49) | 17.28 (24.63)* | 14.28 (21.96) | 22.27 (25.91)* | .205 | <.001 | 21.00 (13.89) | 15; 27 |
| HSV testing | ||||||||
| LP to HSV results | 0.16 (0.38)* | 0.24 (0.38)* | 3.69 (3.21)* | 4.56 (9.63)* | <.001 | <.001 | 0.19 (0.17) | 20.14; 3.80 |
| Acyclovir administration to HSV results | 1.21 (4.21)* | 1.03 (2.16)* | 4.48 (4.96)* | 3.99 (7.69)* | <.001 | <.001 | 0.22 (1.31) | 19.96; 3.80 |
| Acyclovir administration to LP | 1.04 (4.23)* | 0.78 (2.14)* | 0.79 (4.11)* | −0.56 (6.78)* | <.001 | <.001 | 0.03 (1.22) | −0.18; 0 |
| Acyclovir treatment | ||||||||
| Duration of acyclovir | 2.00 (5.71)* | 3.26 (6.59)* | 4.83 (8.62)* | 4.93 (8.46)* | <.001 | <.001 | 12.15 (8.42) | 15.04; 0.64 |
| Admission to acyclovir administration | 1.56 (6.40)* | 2.99 (10.33)* | 2.85 (9.02)* | 5.19 (11.05)* | <.001 | <.001 | 2.45 (2.77) | 0.5; 7.76 |
| LP to acyclovir discontinuation | 0.96 (3.67)* | 2.48 (6.44)* | 4.04 (7.64)* | 5.49 (13.06)* | <.001 | <.001 | 12.12 (8.04) | 15.22; 0.64 |
| HSV result to acyclovir discontinuation | 0.79 (3.50) | 2.23 (6.45)* | 0.35 (8.12) | 0.93 (8.23)* | .154 | <.001 | 11.93 (7.97) | −4.92; −3.15 |
| Abnormal creatinine | ||||||||
| No. with abnormal creatinine at admission (%) | 2 (1.6) | 126 (31.6) | 3 (2.6) | 57 (33.1) | – | – | 1 (7.6) | 0 (0) |
| No. with abnormal creatinine after acyclovir (%) | 3 (2.4) | 157 (39.3) | 8 (7.0) | 74 (43.0) | – | – | 5 (38.5) | 1 (50.0) |
| No. with newly abnormal creatinine after acyclovir administration (%) | 1 (0.8)* | 49 (12.3) | 7 (6.1)* | 29 (16.9) | .021 | .163 | 4 (30.8) | 1 (50) |
| Admission to highest creatinine | 4.73 (2.51) | 9.85 (13.17) | 23.46 (33.75) | 11.39 (13.75) | .776 | .197 | 11.90 (8.74) | 15.49; – |
| Acyclovir administration to highest creatinine | 1.66 (0.73)* | 6.62 (10.12) | 8.50 (9.53)* | 6.03 (8.30) | .012 | .380 | 8.62 (7.62) | 14.99; – |
All values presented except for “No. with abnormal creatinine” are mean (SD), with the unit days. All BioFire+ results except for “No. with abnormal creatinine” are mean (SD), with the unit days. For standalone PCR+ results, the actual values for each case are presented.
Abbreviations: HSV, herpes simplex virus; LP, lumbar puncture; PCR, polymerase chain reaction.
*
Signifies statistical significance at α = 0.05.