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. 2022 Jul 26;14(7):503–512. doi: 10.4252/wjsc.v14.i7.503

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Application of induced pluripotent stem cells in the treatment of diabetes mellitus. The In insulin-dependent diabetes patients, induced pluripotent stem cells (IPSCs)-derived β cells can be induced by autologous IPSCs and then directly or indirectly transplanted back into the body after encapsulation to achieve the effect of diabetes treatment. For patients with monogenic diabetes, such as Wolfram syndrome patients, IPSCs-derived β cells with correct coding can also be obtained after CRISPR-Cas9 gene modification technology and then transplanted. IPSCs: Induced pluripotent stem cells.