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. 2022 Jul 20;11(7):453–464. doi: 10.1302/2046-3758.117.BJR-2022-0019.R1

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© 2022 Author(s) et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/

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Fig. 1 — Degeneration of condylar cartilage in mice with temporomandibular joint (TMJ) osteoarthritis (OA) induced by unilateral anterior crossbite (UAC) stimulation. a) Cartilage degeneration was obvious in the TMJs of UAC mice. b) The thickness of the condylar cartilage and safranin O positive area were significantly decreased in the TMJs of UAC mice. c) The messenger RNA (mRNA) expression of type II collagen (Col-II) and Aggrecan was decreased in the TMJs of UAC mice, accompanied by increased mRNA expression of type X collagen (Col-X), alkaline phosphatase (Alp), and matrix metallopeptidase 13 (Mmp13). d) The mRNA expression of CCAAT/enhancer-binding protein α (Cebpα), fatty acid binding protein 4 (Fabp4), and Perilipin1 was increased in the TMJs of UAC mice. Sham, sham group; 3 WK, 3 weeks; 7 WK, 7 weeks; 11 WK, 11 weeks. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the age-matched sham group, independent-samples t-test.