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. 2022 Jul 25;11(7):503–512. doi: 10.1302/2046-3758.117.BJR-2021-0358.R2

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© 2022 Author(s) et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/

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Fig. 4 — After seven and 14 days of osteogenic induction, the levels of a) runt-related transcription factor 2 (Runx2), b) alkaline phosphatase (ALP), c) osteocalcin (OCN), and d) osteopontin (OPN) were measured by quantitative polymerase chain reaction (qPCR) (n = 3). Secretory leucocyte protease inhibitor (SLPI) increased the expression of Runx2, ALP, OCN, and OPN at different stages of osteogenic differentiation of bone mesenchymal stem cells (BMSCs). Runx2 and ALP increased significantly in the early stage of induction while OCN and OPN were upregulated in the more advanced stage of osteogenic induction. *p < 0.05; **p < 0.01; and ***p < 0.001. mRNA, messenger RNA; NC, negative control.