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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Nat Med. 2022 Mar 21;28(4):814–822. doi: 10.1038/s41591-022-01714-5

Extended Data Fig. 1. Plasma metabolites in EPIC-Norfolk cohort.

Extended Data Fig. 1

A. Manhattan plot of metabolites sorted by their pathways on x-axis and negative log10 of P-value on the y-axis. The cut off horizontal lines on the y-axis highlight the metabolites significantly associated with asthma outcome at a P-value <0.05 and at the Bonferroni threshold (n=35 metabolites, P-value<5.14x10−5). The legend key shape and color show the direction of effect for the metabolites and the main pathway they belong to, respectively. B. Volcano Plot showing the effect size of the metabolites with OR on the x-axis and negative log10 of P-value on the y-axis. The metabolites colored in red are significant at a Bonferroni threshold of P-value<5.14x10−5. Multivariable logistic regression models were used to obtain odds ratio and p-values comparing asthma cases with controls (A, B).