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. Author manuscript; available in PMC: 2023 Mar 7.
Published in final edited form as: Mol Pharm. 2022 Feb 2;19(3):775–787. doi: 10.1021/acs.molpharmaceut.1c00373

Figure 3. Evaluation of self-interactions for grafted antibody variants in a standard formulation condition (pH 6, 10 mM histidine).

Figure 3.

The antibody variants were evaluated using dynamic light scattering to measure diffusion interaction parameters (kD). The parental antibodies are indicated in open circles, while the negatively charged HCDRs are indicated in filled circles and the positively charged HCDR3s are indicated in filled triangles. The values reported are averages for three independent experiments, and the error bars are standard deviations.