Table 3:
Multivariable Cox models and univariate analysis results
| Characteristics | Univariate | Model A1 | Model B2 |
|---|---|---|---|
|
| |||
| HR (P-value) | HR (P-value) | HR (P-value) | |
| Age at Diagnosis (years) | 1.073 (<0.0001) | 1.06 (0.0002) | 1.05 (0.0017) |
| Smoking History | |||
| No | -- | -- | -- |
| Yes | 1.57 (0.1016) | 1.71 (0.0733) | 1.40 (0.2753) |
| Stage (AJCC 8th Edition) | |||
| I&II | -- | -- | -- |
| III&IV | 2.28 (0.0056) | 1.94 (0.0698) | 2.21 (0.0366) |
| Treatment | |||
| Surgery + Radiation + Chemo | -- | -- | -- |
| Radiation + Chemo | 1.79 (0.0706) | 1.43 (0.2874) | 1.22 (0.5644) |
| Surgery Only | 1.23 (0.6503) | 0.76 (0.5985) | 0.83 (0.7240) |
| Surgery + Radiation | 1.11 (0.7864) | 0.81 (0.6550) | 0.93 (0.8656) |
| Other | 3.53 (0.0026) | 2.16 (0.1042) | 1.87 (0.1972) |
| 4Sex | |||
| Male | -- | -- | -- |
| Female | 0.78 (0.5358) | -- | -- |
| High-risk HPV16 SNP Status | |||
| No high-risk SNPs | -- | -- | -- |
| ≥1 high-risk SNP | 7.81 (<0.0001) | -- | 6.12 (<0.0001) |
1
Model A is the model only with traditional factors including age, smoking, stage and treatment.
2
Model B is the model with both traditional factors and HPV16 SNP information.
3
HR for age is for 1-year increase.
4
Gender had p-values of 0.54, 0.84, and 0.64 in univariate analysis, the model with traditional factors, and the model with both traditional factors and HPV SNP information, respectively. With such large p-values, including gender in models yielded decreased model accuracy. Therefore, we presented the models without gender.