Figure 6.
Antitumor activity of H77Bf against SNP xenograft. (A) Evaluation of tumor volume in SNP xenograft models. SNP cells (5×106 cells) were injected subcutaneously into mice. On day 8, 100 µg of H77Bf or control dog IgG in 100 µl PBS were injected intraperitoneally into mice. Additional antibodies were injected on days 14 and 21. Mononuclear cells were also injected surrounding the tumors on days 8, 14 and 21. The tumor volume was measured on days 7, 10, 14, 17, 21, 24 and 28 after the inoculation. Values are presented as the mean ± SEM. **P<0.01 (ANOVA and Sidak's multiple comparisons test). (B) Tumor weight (day 28) was measured from excised SNP xenografts. Values are presented as the mean ± SEM. *P<0.05 (Welch's t-test). (C) Appearance of resected SNP xenografts from the control dog IgG and H77Bf treated groups on day 28 (scale bar, 1 cm).