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. 2022 Jul 22;48(3):164. doi: 10.3892/or.2022.8379

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — FGF5 upregulation reverses the inhibitory effects of miR-491-3p on NSCLC cell malignant phenotype. (A) A549 cells were successfully transfected using pcDNA3.1-FGF5 plasmid and control vector. (B) FGF5 upregulation reversed the inhibitory effects of miR-491-3p on NSCLC cell viability. (C) FGF5 upregulation reversed the inhibitory effects of miR-491-3p on NSCLC cell proliferation. 200× magnification. Scale bar: 50 µm. (D) FGF5 upregulation reversed the inhibitory effects of miR-491-3p on NSCLC cell invasion. 200× magnification. Scale bar: 50 µm. (E) FGF5 upregulation reversed the inhibitory effects of miR-491-3p on NSCLC cell migration. (F) FGF5 upregulation reversed the effects of miR-491-3p on NSCLC cell apoptosis. **P<0.01. FGF5, fibroblast growth factor 5; miR, microRNA; NSCLC, non-small cell lung cancer; NC, negative control.