. Author manuscript; available in PMC: 2022 Aug 4.

Published in final edited form as: Am J Gastroenterol. 2020 Jul;115(7):980–988. doi: 10.14309/ajg.0000000000000639

Table 3.

Level of risk for family member of patients with advanced colorectal polyps

Pathology in Proband	Risk in First Degree Relative, OR/RR (95% CI)
	Advanced Adenoma	Colorectal Cancer

• Advanced adenoma	^*6.05 (2.74–13.36)¹⁰⁴	--

○ Tubular adenoma ≥1 cm	8.59 (3.4–21.45)¹⁰⁴ ^**2.27 (1.01–5.09)¹⁴	3.9 (0.89–17.01)¹⁴
○ Adenoma with villous histology	^***1.65 (1.28–2.14)⁶⁹ 6.28 (2.02–19.53)¹⁰⁴	1.68 (1.29–2.18)⁶⁹
○ Adenoma with high-grade dysplasia	19.98 (2.03–197)¹⁰⁴	--

• Advanced serrated polyp	--	--

in siblings

^**

for composite endpoint of large adenoma and/or CRC

^***

adenoma with villous histology only (not advanced by size or high grade dysplasia)

SSP ≥1 cm, SSP with dysplasia, TSA ≥1 cm

^--

limited available data