Table 1.

Basic information of kinase datasets used in this work

Kinase family	Kinase full namea	Short name	Totalb	Active	Inactive	Ratioc
TK	Epidermal growth factor receptor erbB1	EGFR	8718	4514	4286	0.52
TKL	Serine/threonine-protein kinase B-raf	BRAF	4669	3629	1132	0.78
CAMK	Serine/threonine-protein kinase PIM1	PIM1	4437	3322	1185	0.75
Atypical	Serine/threonine-protein kinase mTOR	mTOR	3924	3390	745	0.86
AGC	Serine/threonine-protein kinase AKT	AKT1	3904	2175	1792	0.56
Other	Serine/threonine-protein kinase Aurora-A	AURKA	3854	2286	1596	0.59
TK	Tyrosine-protein kinase BTK	BTK	2560	1894	746	0.74
CMGC	Cyclin-dependent kinase 2	CDK2	2531	1302	1301	0.51
STE	Mitogen-activated protein kinase kinase kinase kinase 2	MAP4K2	891	280	617	0.31
CK1	Casein kinase I alpha	CK1	801	154	653	0.19

^apreferred name listed on ChEMBL website

^bnumber of molecules in total

^cactive/total ratio