Table 2.
Metabolic pathways significantly affected in gut-liver axis of rats orally exposed to TiO2 NPs
| Sample | Pathway name | pa | FDRb | Impactc | Hit metabolitesd (KEGG ID) |
|---|---|---|---|---|---|
| Liver | Glycerophospholipid metabolism | 0.042 | 1.000 | 0.139 | PC (C00157) |
| Serum | Glycerophospholipid metabolism | 0.000 | 0.003 | 0.206 | PC (C00157); LysoPC(18:1(9Z)) (C04230); GlyceroPC (C00670) |
| Feces | Glycerophospholipid metabolism | 0.000 | 0.036 | 0.164 | PC (C00157); PS(16:0/16:0) (C02737) |
PC, Phosphatidylcholine; PS, Phosphatidylserine
aPrimary p value of pathway enrichment analysis
bThe p value was corrected by FDR
cThe pathway impact was obtained by pathway topology analysis
dName and KEGG ID of differential metabolites that hit the path