Fig. 9.

Downregulation of Dnmt3a promotes the osteogenic capacity of DOP-ASCs in vivo. A Micro-CT showed that the amount of new bone matrix (green) in the Dnmt3a shRNA group was significantly higher than that in DOP-ASC and negative control groups. B BV/TV, BS/BV, and TbTh analysis demonstrated that the osteogenic capacity was greatly increased when Dnmt3a was downregulated by shRNA in vivo. Data represent the mean ± SD of at least three independent experiments, *P < 0.05, **P < 0.01. C: HE and Masson staining of BCP showed that the staining degree in the Dnmt3a shRNA group was stronger than that in DOP-ASC and negative control groups